The typically synthesised derivatives, to mention a few, such as isoflavones, ketamine benzaldehyde or benzyl cinnamate thalidomide mebeverine hydrochloride verapamil and midazolam are currently used in phamacetical drug industry as  antispasmodic and vasodilators. However, a large number of herbal remedies of plant isolates proved just effective and useful as well.

Herbal drugs in general, are often used in urinary tract diseases such as inflammation of the lower urinary tract, kidney and bladder stones and also benign prostata hyperplasia.  They usually show mild aquaretic / diuretic, anti-inflammatory, antibacterial, and antispasmodic actions.  

Aniba canelilla (Mez) is a medicinal plant used in the Amazon folk therapeutic as antispasmodic, antidiarretic, carminative, tonic agent and a stimulant of the digestive and central nervous system. the plant essential oil has analgesic activity. 

The hydroalcoholic extracts of Achillea millefolium L. (AM) and Artemisia vulgaris L. (AV), both belonging to the Asteraceae family confirm their folk use as analgesic, anti-inflammatory and antispasmodic agents.  

 The antispasmodic effects of methyleugenol from the essential oil of Artemisia dracunculus is reported to possess bitter, stimulant, tonic, antispasmodic and anthelmintic properties.  Artemisia scoparia Waldst and kit (Compositae) is an important source of chems of immense medicinal and pharmaceutical importance such as Scoparone, Rutin and Esculetin which are effective as immunosuppressants, hepatoprotective, antispasmodic, hypotensive, antiatherogenic, anti-inflammatory agents. 

St John’s Wart (Hypericum perforatum) is famous for its many medicinal uses

The crude extract of aerial parts and its fractions were studied in vitro for its possible spasmolytic and bronchodilator activities. The composites of which are sold as pills in over-the-counter herbal remedies in pharmacies.

Of the several hallucinogenic plant constiuents, such as papavrine, morphine and opium were shown to have sedative and antispasmodic effects, besides their addictive nature and other deleterious nature when often misused.

Opium poppy (Papaver somniferum) is an ancient, highly significant and popular plant species with proven pharmaceutical value esp. against human chronic diseases in modern medicine.  Among the opium alkaloids, morphine is a strong analgesic, while codeine is antitussive and papaverine antispasmodic.  Besides being a potent pain killer, morphine, the largest component of opium, exhibits a combination of depression and stimulation in the central nervous system.  India is a unique country where opium poppy is legitimately cultivated for gum latex as per WHO guidelines.

Hyoscine, another hallucinogenic and poisonous plant constituents experience wide use in phamacetical drug industry. 

Hyoscine butylbromide (tradenames: Buscopan/Buscapina) is an antispasmodic drug for the treatment of abdominal pain associated with gastrointestinal cramping.  As a hyoscine derivative it competitively inhibits muscarinic acetylcholine receptors on smooth muscle cells in the gastrointestinal tract...